With appearances on many films, including The Cell (2000), de los Reyes currently portrays Antonio Vega on the ABC soap opera, One Life to Live, a role he has played since 1995. In 2001 he starred in a made for TV movie, The Way She Moves, starring Annabeth Gish and fellow soap opera star Daniel Cosgrove. He guest-starred as a murder suspect on the NBC hit show Law & Order during the 2004-2005 season. He also starred in the controversial film LOVE and SUICIDE, playing the tormented 'Thomas', shot on location in Havana, Cuba. He also appeared in Toni Braxton's 'Spanish Guitar (song)' Music Video.
In 1995, de los Reyes starred with James Woods, Ed Harris and Sir Anthony Hopkins in Oliver Stone's controversial biopic, Nixon, playing convicted Watergate burglar, Eugenio Martínez. In April 2007, Kamar had surgery on his arm which he injured doing the role of Antonio Vega on One Life To Live. Robert Montano took over the role of Antonio Vega for him as he recovered.
Kamar recently married his longtime girlfriend, actress Sherri Saum on May 19, 2007 in New York City.