Claywell was raised in Greensboro, North Carolina. In high school he played both basketball and soccer. He has even travelled abroad to play soccer. He was also known as the class clown. After high school he attended college at North Carolina State University, where he graduated with a major in architecture and a minor in theatre. While at NC State he was a member of the Phi Delta Theta fraternity. His nickname there was 'Spoda'.
Claywell has two older siblings, a brother, Christopher, and a sister, Traci.
Brett Claywell is now bicoastal with a home both in North Carolina and California.
- Babysitter Wanted (2008) (Movie) ... Hal (post-production)
- Legacy (2008) (Movie) ... Jeff Cook (post-production)
- Senior Skip Day (Movie) (2007) ... Carl Smith
- The Final Season (Movie) (2007) ... Patrick Iverson
- One Tree Hill (TV series) (2003)... Tim Smith (2003-2008) (recurring)
- Strike The Tent (Movie) (2005) ... Union Soldier (scenes deleted)
- 20 Funerals (Movie) (2004) ... Hughes
- Stateside (Movie) (2004) ... Marine, Company 1021
- Dawson's Creek (TV Series) Episode: "Rock Bottom" (2003) ... Set P.A.
- Dawson's Creek (TV Series) Episode: "Everything Put Together Falls Apart" (2002) ... Dancer